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Physical Activity Analysis of Rheumatoid Arthri...

Physical Activity Analysis of Rheumatoid Arthritis Patients

These slides contain a summary of my Master's research project, which focuses on analysing the physical activities of rheumatoid arthritis patients.

Elvyna Tunggawan

November 10, 2020
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  1. 2 Image source: [5] What is rheumatoid arthritis (RA)? •

    Autoimmune disorder, symmetrical nature [2, 3] • Limited physical activity, leads to frustration & higher risk of having heart disease [1, 4] Research Problem • Any changes in the activities after RA patients got drugs treatment? • Does spending more time in particular activity affect their health? [1] Ahlstrand, I., Björk, M., Thyberg, I., Börsbo, B., and Falkmer, T. (2012). Pain and daily activities in rheumatoid arthritis. Disability and Rehabilitation, 34(15):1245–1253. [2] Bullock, J., Rizvi, S. A., Saleh, A. M., Ahmed, S. S., Do, D. P., Ansari, R. A., and Ahmed, J. (2018). Rheumatoid Arthritis: A Brief Overview of the Treatment. Medical Principles and Practice, 27(6):501–507. [3] Dewing, K. A., Setter, S. M., and Slusher, B. A. (2012). Osteoarthritis and Rheumatoid Arthritis 2012: Pathophysiology, Diagnosis, and Treatment. Clinical Advisor. [4] Fenton, S. A., van Zanten, J. J. V., Duda, J. L., Metsios, G. S., and Kitas, G. D. (2018). Sedentary behaviour in rheumatoid arthritis: definition, measurement and implications for health. Rheumatology, 57(2):213–226. [5] Posalski, J., & Weisman, M. (2009). Articular and Periarticular Manifestations of Established Rheumatoid Arthritis. In Rheumatoid Arthritis, chapter 5A, pages 49-61, Mosby, Philadelphia, USA.
  2. Literature Review • Positive association between sedentary behaviour and cardiovascular

    disease risk in RA patients [1, 2] 3 + + = 24 hours Image source: HealingExercise.org [1] Fenton, S. A., van Zanten, J. J. V., Kitas, G. D., Duda, J. L., Rouse, P. C., Yu, C.-a., and Metsios, G. S. (2017). Sedentary behaviour is associated with increased long-term cardiovascular risk in patients with rheumatoid arthritis independently of moderate-to-vigorous physical activity. BMC Musculoskeletal Disorders, 18(1):131. [2] Hammam, N., Ezeugwu, V. E., Rumsey, D. G., Manns, P. J., and Pritchard-Wiart, L. (2019). Physical activity, sedentary behavior, and long-term cardiovascular risk in individuals with rheumatoid arthritis. The Physician and Sportsmedicine, 47(4):463–470.
  3. Datasets 4 Activity Data Image sources: actigraphcorp.com & inventrn.org Health

    Data EDA: Step Count Cyclic pattern: more steps during the day
  4. Activity Compositions during the Day* No statistically significant difference of

    the activities across the periods • ActiGraph: p = 0.285 • activPAL: p = 0.405 7 *between 6 AM (inclusive) and 9 PM (exclusive)
  5. What is the association between each activity and their health?

    8 +1 hour of stepping a day … • Baseline: up to +11.39 points (avg: 5.85) • Follow-up: up to +9.42 points (avg: 4.57)
  6. Conclusion 9 Future Work • No statistically significant change in

    the activities. After the treatment was given: ◦ On average, fewer step counts -- but they took more steps during the day! ◦ Lower odds of being sedentary • Spending more time in stepping by an hour a day improves the overall health quality by 5.85 and 4.57 points in the baseline and follow-up period, respectively • Improvement of ActiGraph activity type classification [1, 3] • Assess the one-to-one relationship between each activity type [2] [1] Ahmadi, M., O’Neil, M., Fragala-Pinkham, M., Lennon, N., and Trost, S. (2018). Machine learning algorithms for activity recognition in ambulant children and adolescents with cerebral palsy. Journal of Neuroengineering and Rehabilitation, 15(105). [2] Dumuid, D., Željko Pedišić, Stanford, T. E., Martín-Fernández, J.-A., Hron, K., Maher, C. A., Lewis, L. K., and Olds, T. (2019). The compositional isotemporal substitution model: A method for estimating changes in a health outcome for reallocation of time between sleep, physical activity and sedentary behaviour. Statistical Methods in Medical Research, 28(3):846–857. [3] Sasaki, J. E., Hickey, A., Staudenmayer, J., John, D., Kent, J. A., and Freedson, P. S. (2016). Performance of Activity Classification Algorithms in Free-Living Older Adults. Medicine and Science in Sports and Exercise, 48(5):941–950.