Node.js is a very popular framework for developing asynchronous, event-driven, reactive applications. JBoss Data Grid, an in-memory distributed database designed for fast access to large volumes of data and scalability, has recently gained compatibility with Node.js enabling reactive applications to use it as persistence layer. Thanks to near caching, JBoss Data Grid offers excellent response times for data queried regularly, and its continuous remote event support means data can get pushed from the data grid to the Node.js application instead of having to wait for the data grid to serve it. In this talk we will be showing how to build Node.js applications that use JBoss Data Grid as persistence layer.