j 4 j 5 j 6 =∑ l 1 l 2 l 3 l 4 l 5 l 6 l 7 G(l 1 ,l 2 ,l 3 ,l 4 ,l 5 ,l 6 ,l 7 ) ×u l 1 j 1 u l 2 j 2 u l 3 j 3 u l 4 j 4 u l 5 j 5 u l 6 j 6 u l 7 i (A) u l1j1 :96 wells (cells), l 1 =1 (B) u l2j2 : genotype APP_NL-F-G vs C57Bl/6, l 2 =1 (C) u l3j3 : Cortex vs Hippocampus, l 3 =1 (D) u l4j4 : 3, 6, 12, 21 weeks , l 4 =2 (E) u l5j5 : female vs male, l 5 =1 (F) u l6j6 : 4 plates , l 1 =1 → l 7 =2 with G(1,1,1,2,1,1,l 7 ) (the largest absolute values)