Amazon Aurora for PostgreSQL combines the flexibility of open-source databases with cloud-native scalability, offering high availability and enterprise-grade performance at a fraction of traditional costs. This guide explores Aurora’s decoupled storage-compute architecture, quorum-based replication, and log-driven design that minimizes I/O overhead while ensuring rapid recovery. It provides actionable strategies for instance sizing, query tuning, and indexing (including BRIN and GIN indexes), alongside Aurora-specific optimizations like Fast Clone for instant environment provisioning and I/O-optimized configurations for write-heavy workloads. Learn to leverage Performance Insights for real-time diagnostics, implement connection pooling with RDS Proxy or PgBouncer, and automate maintenance with autovacuum tuning. Advanced techniques such as table partitioning, materialized views, and global database deployments are covered to help architects and developers maximize throughput, reduce latency, and maintain resilience in distributed systems. Ideal for teams aiming to optimize OLTP/OLAP workloads, scale efficiently, and reduce operational overhead in cloud environments.