Static wireframes are a drag on the whole design process. Prototyping makes things a little better allowing you to stitch together static wireframes or mockups while adding basic interactions. Rapid prototyping with HTML, CSS, and JavaScript is even better, faster, increases collaboration and improves the iteration process. Kill your wireframes. Long live rapid prototyping.
Given originally at ConvergeSE 2012, then for UX Web Summit, Confoo & a complete update for UX Madison.