(出典) *4:https://www.mdpi.com/1660-4601/18/6/2908 *5: 1) Sandrine Touzet,Muriel Rabilloud,Hans Boehringer, Enriqueta Barranco,Rene Ecochard: Relationship between sleep and secretion of gonadotropin and ovarian hormones in women with normal cycles REPRODUCTIVE ENDOCRINEOLOGY 2022 Apr 77(4) P738-744 2) Christina C.Lawson,Elizabeth A.Whelan,Eileen N. Lividoti Hibert, Donna Spiegelman, Eva S. Schernhammer, Janet W. Rich-Edwards: Rotating shift work and menstrual cycle characteristics Epidemiology,2022 May;22(3):305-312 3) Renae C.Fernandoes,Vivienne M.Moore,Jennifer L.Marino, Mellissa J. Whitrow,Michael J. Davies: Night Shift Among Women: Is it associated With Difficulty Conceiving a First Birth?:Public Health 01 Dec 2020 4) Yasindu Samaraweera,Chrishantha Abeysena:Maternal sleep deprivation, sedentary lifestyle and cooking smoke: Risk factors for miscarriage: A case control study ,Australian and New Zealand journal of Obstetrics and Gynecology, Aug 2010 50(4):352-7 *6:https://www.science.org/doi/abs/10.1126/science.1241224 / https://www.science.org/doi/abs/10.1126/science.abb8739 ✓夜間勤務などの不規則な⽣活は不妊率を40%上げ、流産率を2倍にする。 →性ホルモンのバランスに悪影響が出る、睡眠不⾜のストレスにより炎症反応が起こる (*5) ✓若年期からの睡眠課題が認知症発症に繋がる。 →ノンレム睡眠が不⾜するとグリンパティック系が活性化して、アミロイドβを排出。 アミロイドβの蓄積量が閾値を超えるとアルツハイマー病を発症 (*6)