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on nanofluidics and why it is so great

on nanofluidics and why it is so great

... given jointly with Jan Eijkel at GRC, Oxford 2005.

andreas manz

August 08, 2005
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  1. proton transport blocked Water dipole reorientation  no dipole chain

     no Grotthus proton conduction Tajkhorshid et al., Science, 296 (2002) 525
  2. • Na+/K+ separating force (Energy / distance ) : 1ATP

    / (membrane thickness) = 14 kT / 4 nm  14 pN • Pumps against E-field of 70 mV / 4 nm = 1.75e7 V/m • Electrophoresis: max. 2e5 V/m  0.03 pN on unit charge • Almost isothermal, ~ 100% efficiency • Energy dissipation only where needed
  3. Why nanofluidics is so great • Single molecule studies •

    Freedom of nanoarchitecture instead of random separation structure – Sophisticated sieving (continuous flow), ratchets • From nature: active transport for separation – efficient – high separating field gradients – specific