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on nanofluidics and why it is so great
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andreas manz
August 08, 2005
Research
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on nanofluidics and why it is so great
... given jointly with Jan Eijkel at GRC, Oxford 2005.
andreas manz
August 08, 2005
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Transcript
LATERNA MAGICA
REFE RENC E
LATERNA MAGICA
GLASS GLASS DEVICE
LATERNA MAGICA
THE OLDE BUNNY TRICK
MY LATEST AIR PUMP
THE OLDE BUNNY TRICK
THE OLDE BUNNY TRICK
microfluidics
Microf luidics
waves
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On nanofluidics and why it’s so great S. Holmes, Baker
Street, London
DNA research confinement & reading Tegenfeldt 2004, Craighead group Kasianowicz
, 1996
Nanotechnology: spatial design instead of randomness Korda, 2002 Huang, 2004
Continuous flow!
Thermal ratchets: employ noise Koss, 2003 Bader, 2004 Separation speed
scales with 1/d2 !
Actin-myosin movement by ATP-biased Brownian motion (Kitamura 1999)
Rustom, 2004
Natura artis magistra (or: bottom-up and top-down) There’s plenty of
sophistication at the bottom
Bottom-up: Aquaporins specific transport
proton transport blocked Water dipole reorientation  no dipole chain
 no Grotthus proton conduction Tajkhorshid et al., Science, 296 (2002) 525
Aquaporin http://www.ks.uiuc.edu/Research/aquaporins/
Bottom-up: Na+ K+ ATPase active transport through cell wall
Separation!
• Na+/K+ separating force (Energy / distance ) : 1ATP
/ (membrane thickness) = 14 kT / 4 nm  14 pN • Pumps against E-field of 70 mV / 4 nm = 1.75e7 V/m • Electrophoresis: max. 2e5 V/m  0.03 pN on unit charge • Almost isothermal, ~ 100% efficiency • Energy dissipation only where needed
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Combining top/down and bottom/up Cornell, 1997
Why nanofluidics is so great • Single molecule studies •
Freedom of nanoarchitecture instead of random separation structure – Sophisticated sieving (continuous flow), ratchets • From nature: active transport for separation – efficient – high separating field gradients – specific
Now, isn’t that great???
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