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Tc99m

Tsung-Yung Lu
December 14, 2016

 Tc99m

放射性標幟 鎝

Tsung-Yung Lu

December 14, 2016
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  1. 9xTc isotope Half-life Reaction channel 93Tc 93mTc 2.75 h 43.5

    m 93Mo(p,n) 94Mo(p,2n) 95Mo(p,3n) 94Tc 94mTc 293 m 52.0 m 94Mo(p,n) 95Mo(p,2n) 96Mo(p,3n) 97Mo(p,4n) 95Tc 95mTc 20.0 h 61 d 95Mo(p,n) 96Mo(p,2n) 97Mo(p,3n) 98Mo(p,4n) 100Mo(p,6n) 96Tc 96mTc 4.28 d 51.5 m 96Mo(p,n) 97Mo(p,2n) 98Mo(p,3n) 100Mo(p,5n) 97Tc 97mTc 4.2x10^6y 91 d 97Mo(p,n) 98Mo(p,2n) 100Mo(p,4n) 98Tc 4.2x10^6 y 100Mo(p,3n) 99Tc 99mTc 2.1x10^5y 6.01 h 100Mo(p,2n) 100Tc 15.46 s 100Mo(p,n)
  2. •99Mo衰變後會產生產物為過鎝酸鹽(TcO 4 -1) •因為TcO 4 -1(過鎝酸鹽)為單電荷,對氧化鋁(Al 2 O 3 )管

    柱的鍵結力並不如鉬酸鹽陰離子(MoO 4 2-)那麼強, 所以我們可以容易的用0.9%NaCl的生理食鹽水將 含有99mTc的過鎝酸鹽(TcO 4 -1)流洗出來而不會將鉬 酸鹽陰離子(MoO 4 2-)移出 P.288 L.6 P.289 L.1
  3. Name Investigation Route of administration In-vitro / in-vivo Imaging /

    non-imaging Tc99m-pertechnetate Thyroid uptake and thyroid imaging Stomach and salivary gland imaging Meckel's diverticulum imaging Brain imaging Micturating cystogram First pass blood flow imaging First pass peripheral vascular imaging IV In-vivo Imaging Tc99m-pertechnetate Lacrimal imaging Eye drops In-vivo Imaging Tc99m-Human albumin Cardiac blood pool imaging IV In-vivo Imaging Tc99m-Human albumin Peripheral vascular imaging IV In-vivo Imaging Tc99m-Human albumin macroaggregates or microspheres Lung perfusion imaging IV In-vivo Imaging Tc99m-Human albumin macroaggregates or microspheres Lung perfusion imaging with venography IV In-vivo Imaging Tc99m-Phosphonates and phosphates (MDP/HDP) Bone imaging IV In-vivo Imaging Tc99m-Phosphonates and phosphates Myocardial imaging IV In-vivo Imaging Tc99m-DTPA (diethylenetriaminepenta-acetic acid) Renal imaging First pass blood flow studies Brain imaging IV In-vivo Imaging Tc99m-DTPA (diethylenetriaminepenta-acetic acid) Lung ventilation imaging Aerosol inhalation In-vivo Imaging Tc99m-DMSA(V) (dimercaptosuccinic acid) Tumor imaging IV In-vivo Imaging Tc99m-DMSA(III) (dimercaptosuccinic acid) Renal imaging IV In-vivo Imaging Tc99m-Colloid Bone marrow imaging GI Bleeding IV In-vivo Imaging Tc99m-Colloid Lymph node imaging Interstitial In-vivo Imaging Tc99m-Colloid Esophageal transit and reflux imaging Gastric emptying imaging Oral In-vivo Imaging Tc99m-Colloid Lacrimal imaging Eye drops In-vivo Imaging Tc99m-HIDA (Hepatic iminodiacetic acid) Functional biliary system imaging IV In-vivo Imaging Tc99m-Denatured (heat damaged) red blood cells Red cell volume Spleen imaging IV In-vitro Non-imaging Tc99m-Whole red blood cells GI bleeding Cardiac blood pool imaging Peripheral vascular imaging IV In-vivo Imaging Tc99m-MAG3 (mercaptoacetyltriglycine) Renal imaging First pass blood flow imaging IV In-vivo Imaging Tc99m-Exametazime (HMPAO) Cerebral blood flow imaging IV In-vivo Imaging Tc99m-Exametazime labelled leucocytes Infection/inflammation imaging IV In-vivo Imaging Tc99m-Sestamibi (MIBI - methoxy isobutyl isonitrile) Parathyroid imaging Non-specific tumor imaging Thyroid tumor imaging Breast imaging Myocardial imaging IV In-vivo Imaging Tc99m-Sulesomab (IMMU-MN3 murine Fab'-SH antigranulocyte monoclonal antibody fragments) Infection/inflammation imaging IV In-vivo Imaging Tc99m-Technegas Lung ventilation imaging Inhalation In-vivo Imaging Tc99m-Human immunoglobulin Infection/inflammation imaging IV In-vivo Imaging Tc99m-Tetrofosmin Parathyroid imaging Myocardial imaging IV In-vivo Imaging Tc99m-ECD (ethyl cysteinate dimer) Brain imaging----- IV In-vivo Imaging
  4. Organ Estimated absorbed radiation dose* With normal hepatic function With

    parenchymal liver disease (intermediate/advanced) mGy/ MBq rad/ mCi mGy/ MBq rad/ mCi Spleen 0.077 0.29 0.14 0.52 Liver 0.074 0.27 0.042 0.16 Pancreas 0.012 0.044 0.018 0.066 Red marrow 0.011 0.041 0.023 0.085 Adrenals 0.01 0.037 0.0098 0.036 Kidneys 0.0097 0.036 0.011 0.041 Bone surfaces 0.0064 0.024 0.012 0.044 Stomach wall 0.0062 0.023 0.0098 0.036 Large intestine wall (upper) 0.0056 0.021 0.0049 0.018 Lungs 0.0055 0.20 0.0048 0.018 Small intestine 0.0043 0.016 0.0046 0.017 Breast 0.0027 0.01 0.0024 0.0089 Ovaries 0.0022 0.0081 0.0033 0.012 Uterus 0.0019 0.0070 0.0028 0.01 Large intestine wall (lower) 0.0018 0.0067 0.0031 0.011 Bladder wall 0.0011 0.0041 0.0016 0.0059 Thyroid 0.00079 0.0029 0.0011 0.0041 Testes 0.00062 0.0023 0.00095 0.0035 Other tissue 0.0028 0.01 0.0031 0.011
  5. T

  6. Reference: Properties, Uses, Radiochemical PUrity andCalibration of Tc99m E. M.

    Smith, Sc.D.1 Recent Achievements in Tc-99m Radiopharmaceutical Direct Production by Medical Cyclotrons ISSN: 0363-9045 Alessandra Boschi, Petra Martini, Micol Pasquali & Licia Uccelli Quality assurance of Mo-99/Tc-99m radionuclide generators Nikolay Uzunov1,5, Galina Yordanova1 , Seniha Salim1 , Natalya Stancheva2 , Vanya Mineva2 , Laura Meléndez-Alafort3 , Antonio Rosato4,5 95gTc and 96gTc as alternatives to medical radioisotope 99mTc Takehito Hayakawa a, *, Yuichi Hatsukawa a , Toru Tanimori b http://www.wikiwand.com/zh-mo/%E9%94%9D http://www.wikiwand.com/zh- mo/%E6%A0%B8%E5%8C%BB%E5%AD%A6%E6%94%BE%E5%B0%84%E6%80 %A7%E8%8D%AF%E7%89%A9%E5%88%97%E8%A1%A8#/%E9%94%9D-99m https://www.youtube.com/watch?v=rcTBlq-53wI