We study the convergence analysis for general degenerate and non-reversible stochastic differential equations (SDEs). We apply the Lyapunov method to analyze the Fokker-Planck equation, in which the Lyapunov functional is chosen as a weighted relative Fisher information functional. We derive a structure condition and formulate the Lyapunov constant explicitly. We prove the exponential convergence result for the probability density function towards its invariant distribution in the L1 distance. Two examples are presented: underdamped Langevin dynamics with variable diffusion matrices and three oscillator chain models with nearest-neighbor couplings.