clustering analysis A: glycerophosphocholine-high (n=79) B: amino acid-high, polyunsaturated fatty acid-low (n=72) C: amino acid-high, glycerophospholipid-low (n=363) D: glycerophospholipid-high (n=177) E: mixed (n=227) Derived metabotypes Nasopharyngeal airway metabolome endotyping of severe bronchiolitis in infancy and risk of childhood asthma Association of metabotypes with clinical outcomes Zhu et al. JACI, 2022b Recurrent wheeze by age 3 years with asthma at age 5 years A: glycerophosphocholine-high B: amino acid-high, polyunsaturated fatty acid-low VS. Asthma at age 5 years Adjusted odds ratio=2.18 (95% CI, 1.03-4.71) Adjusted hazards ratio=2.52 (95% CI, 1.16-5.47)